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George B. Benedek Group
Alfred H. Caspary Professor of Physics and Biological Physics in the Department of Physics
and
Professor of Physics and Health Sciences and Technology in the
Harvard-MIT Division of Health Sciences and Technology

Contact Information


Mailing Address:

Massachusetts Institute of Technology,
77 Massachusetts Avenue,
Rm 13-2018
Cambridge, MA 02139-4307

Phone: (617) 253-4826



Email:   ywang09@mit.edu

 


Ying Wang
Research Associate
Research Projects

  • Phase Transitions in Antibody Solutions Associated with Cryoglobulinemia and Pharmaceutical Formulations

  • Oligomerization of Lipid Conjugated Peptide Amphiphiles




Publications



  1. Y. Wang, A. Lomakin, S. Kanai, R. Alex, G.B. Benedek, "Transformation of oligomers of lipidated peptide Induced by Change in pH."Molecular Pharmaceutics 12(2), 411-419 (2015).[PDF]

  1. Y. Wang, R.F. Latypov, A. Lomakin, J.A. Meyer, B.A. Kerwin, S. Vunnum, G.B. Benedek, "Quantitative evaluation of colloidal stability of antibody solutions using PEG-induced liquid-liquid phase separation."Molecular Pharmaceutics 11(5), 1391-1402 (2014).[PDF]

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  1. Y. Wang, A. Lomakin, R.F. Latypov, J.P. Laubach, T. Hideshima, P.G. Richardson, N.C. Munshi, K.C. Anderson, G.B. Benedek, "Phase transitions in human IgG solutions."J. Chem. Phys. 139, 121904(1-9) (2013).[PDF]

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  1. Y. Wang, A. Lomakin, T. Hideshima, J.P. Laubach, O.O. Ogun, P.G. Richardson, N.C. Munshi, K.C. Anderson, G.B. Benedek, "Pathological crystallization of human immunoglobulins."Proc. Natl. Acad.Sci. USA, 109, 13359–13361 (2012).[PDF]

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  1. Y. Wang, A. Lomakin, R.F. Latypov, G.B. Benedek, "Phase separation in solutions of monoclonal antibodies and the effect of human serum albumin" Proc. Natl. Acad.Sci. USA, 108, 16606–16611 (2011).[PDF]

.
  1. Y. Wang, A. Lomakin, J.J. McManus, O. Ogun, G.B. Benedek, "Phase behavior of mixtures of human lens proteins Gamma D and Beta B1" Proc. Natl. Acad.Sci. USA, 107, 13282–13287 (2010). [PDF]

  1. O. Annunziata, A. Payne and Y. Wang, “Solubility of lysozyme in the presence of aqueous chloride salts: common-ion effect and its role on solubility and crystal thermodynamics.”, J. Am. Chem. Soc., 130, 13347-13352 (2008). [PDF]

  1. Y. Wang and O. Annunziata, “Liquid-liquid phase transition of protein aqueous solutions isothermally induced by protein crosslinking”, Langmuir, 24, 2799-2807 (2008).[PDF]

  1. Y. Wang and O. Annunziata, “Comparison between protein-PEG interactions and the effect of PEG on protein-protein interactions using the liquid-liquid phase transition”, J. Phys. Chem. B, 111, 1222-1230 (2007).[PDF]


Education

Jan. 2009- present        Postdoctoral Associate
                                   Massachusetts Institute of Technology, MA, USA.
                                  

Sept.2004- Dec. 2008    Ph.D., Chemistry
                                   Texas Christian University, TX, USA.
                                   Dissertation Title: Protein condensation in crowded aqueous solutions.
                                

Sept.1999- Jul. 2003     B.S., Chemistry
                                   Tsinghua University, Beijing, China.
                                   Thesis Title: Identification and Classification of Chinese Herbal Medicine using
                                   FTIR and Clustering Analysis.